Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The localization of de novo DNA methyltransferase DNMT3A is facilitated by its PWWP domain recognizing histone H3 lysine 36 (H3K36) methylation(1,2) and is...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Weinberg, Daniel N., Rosenbaum, Phillip, Chen, Xiao, Barrows, Douglas, Horth, Cynthia, Marunde, Matthew R., Popova, Irina K., Gillespie, Zachary B., Keogh, Michael-Christopher, Lu, Chao, Majewski, Jacek, Allis, C. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283687/
https://ncbi.nlm.nih.gov/pubmed/33986537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00856-5
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