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Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation
The shelterin complex plays dual functions in telomere homeostasis by recruiting telomerase and preventing the activation of a DNA damage response at telomeric ends. Somatic stem cells require telomerase activity, as evidenced by progressive stem cell loss leading to bone marrow failure in hereditar...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3967656/ https://ncbi.nlm.nih.gov/pubmed/24316971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67871 |
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