Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis

Adrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutation that exhibits a pleiotropic phenotype with perinatal lethality. Mutant acd embryos have caudal truncation, vertebral segmentation defects, hydronephrosis, and limb hypoplasia, resembling humans with Caudal Regression...

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Bibliographic Details
Main Authors: Vlangos, Christopher N., O’Connor, Bridget C., Morley, Madeleine J., Krause, Andrea S., Osawa, Gail A., Keegan, Catherine E.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298753/
https://ncbi.nlm.nih.gov/pubmed/19660449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.07.038
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