Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation

The shelterin complex plays dual functions in telomere homeostasis by recruiting telomerase and preventing the activation of a DNA damage response at telomeric ends. Somatic stem cells require telomerase activity, as evidenced by progressive stem cell loss leading to bone marrow failure in hereditar...

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Detalhes bibliográficos
Main Authors: Jones, Morgan, Osawa, Gail, Regal, Joshua A., Weinberg, Daniel N., Taggart, James, Kocak, Hande, Friedman, Ann, Ferguson, David O., Keegan, Catherine E., Maillard, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967656/
https://ncbi.nlm.nih.gov/pubmed/24316971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67871
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