Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

A high percentage of pediatric gliomas and bone tumors reportedly harbor missense mutations at glycine 34 in genes encoding histone variant H3.3. We find that these H3.3 G34 mutations directly alter the enhancer chromatin landscape of mesenchymal stem cells by impeding methylation at lysine 36 on hi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jain, Siddhant U., Khazaei, Sima, Marchione, Dylan M., Lundgren, Stefan M., Wang, Xiaoshi, Weinberg, Daniel N., Deshmukh, Shriya, Juretic, Nikoleta, Lu, Chao, Allis, C. David, Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959516/
https://ncbi.nlm.nih.gov/pubmed/33067396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006076117
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