Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells

Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In Drosophila, polycomb binding sites are dynamic chromatin regions enriched with the histone variant H3.3. Here we show that in mouse embryonic s...

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Detalhes bibliográficos
Main Authors: Banaszynski, Laura A., Wen, Duancheng, Dewell, Scott, Whitcomb, Sarah J., Lin, Mingyan, Diaz, Nichole, Elsässer, Simon J., Chapgier, Ariane, Goldberg, Aaron D., Canaani, Eli, Rafii, Shahin, Zheng, Deyou, Allis, C. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838450/
https://ncbi.nlm.nih.gov/pubmed/24074864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.08.061
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