Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

A high percentage of pediatric gliomas and bone tumors reportedly harbor missense mutations at glycine 34 in genes encoding histone variant H3.3. We find that these H3.3 G34 mutations directly alter the enhancer chromatin landscape of mesenchymal stem cells by impeding methylation at lysine 36 on hi...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Jain, Siddhant U., Khazaei, Sima, Marchione, Dylan M., Lundgren, Stefan M., Wang, Xiaoshi, Weinberg, Daniel N., Deshmukh, Shriya, Juretic, Nikoleta, Lu, Chao, Allis, C. David, Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959516/
https://ncbi.nlm.nih.gov/pubmed/33067396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006076117
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