Histone H3.3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis

Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here, we show that 50% of G34R/V-tumours (n=95) bear activating PDGFRA mutations that display stron...

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出版年:Cell
主要な著者: Chen, Carol C.L., Deshmukh, Shriya, Jessa, Selin, Hadjadj, Djihad, Lisi, Véronique, Andrade, Augusto Faria, Faury, Damien, Jawhar, Wajih, Dali, Rola, Suzuki, Hiromichi, Pathania, Manav, A, Deli, Dubois, Frank, Woodward, Eleanor, Hébert, Steven, Coutelier, Marie, Karamchandani, Jason, Albrecht, Steffen, Brandner, Sebastian, De Jay, Nicolas, Gayden, Tenzin, Bajic, Andrea, Harutyunyan, Ashot S., Marchione, Dylan M., Mikael, Leonie G., Juretic, Nikoleta, Zeinieh, Michele, Russo, Caterina, Maestro, Nicola, Bassenden, Angelia V., Hauser, Peter, Virga, József, Bognar, Laszlo, Klekner, Almos, Zapotocky, Michal, Vicha, Ales, Krskova, Lenka, Vanova, Katerina, Zamecnik, Josef, Sumerauer, David, Ekert, Paul G., Ziegler, David S., Ellezam, Benjamin, Filbin, Mariella G., Blanchette, Mathieu, Hansford, Jordan R., Khuong-Quang, Dong-Anh, Berghuis, Albert M., Weil, Alexander G., Garcia, Benjamin A., Garzia, Livia, Mack, Stephen C., Beroukhim, Rameen, Ligon, Keith L., Taylor, Michael D., Bandopadhayay, Pratiti, Kramm, Christoph, Pfister, Stefan M., Korshunov, Andrey, Sturm, Dominik, Jones, David T.W., Salomoni, Paolo, Kleinman, Claudia L., Jabado, Nada
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791404/
https://ncbi.nlm.nih.gov/pubmed/33259802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.012
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