H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and EZHIP are competitive inhibitors of Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase acti...

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出版年:Mol Cell
主要な著者: Jain, Siddhant U., Rashoff, Andrew Q., Krabbenhoft, Samuel D., Hoelper, Dominik, Do, Truman J., Gibson, Tyler J., Lundgren, Stefan M., Bondra, Eliana R., Deshmukh, Shriya, Harutyunyan, Ashot S., Juretic, Nikoleta, Jabado, Nada, Harrison, Melissa M., Lewis, Peter W.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
https://ncbi.nlm.nih.gov/pubmed/33049227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.09.028
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