H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its additional effects on the epigenome. Here, we use isogenic gliom...

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Udgivet i:Cell Rep
Main Authors: Harutyunyan, Ashot S., Chen, Haifen, Lu, Tianyuan, Horth, Cynthia, Nikbakht, Hamid, Krug, Brian, Russo, Caterina, Bareke, Eric, Marchione, Dylan M., Coradin, Mariel, Garcia, Benjamin A., Jabado, Nada, Majewski, Jacek
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703850/
https://ncbi.nlm.nih.gov/pubmed/33207202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108390
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