H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and EZHIP are competitive inhibitors of Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase acti...

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Publié dans:Mol Cell
Auteurs principaux: Jain, Siddhant U., Rashoff, Andrew Q., Krabbenhoft, Samuel D., Hoelper, Dominik, Do, Truman J., Gibson, Tyler J., Lundgren, Stefan M., Bondra, Eliana R., Deshmukh, Shriya, Harutyunyan, Ashot S., Juretic, Nikoleta, Jabado, Nada, Harrison, Melissa M., Lewis, Peter W.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
https://ncbi.nlm.nih.gov/pubmed/33049227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.09.028
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