H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and EZHIP are competitive inhibitors of Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase acti...

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Vydáno v:Mol Cell
Hlavní autoři: Jain, Siddhant U., Rashoff, Andrew Q., Krabbenhoft, Samuel D., Hoelper, Dominik, Do, Truman J., Gibson, Tyler J., Lundgren, Stefan M., Bondra, Eliana R., Deshmukh, Shriya, Harutyunyan, Ashot S., Juretic, Nikoleta, Jabado, Nada, Harrison, Melissa M., Lewis, Peter W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
https://ncbi.nlm.nih.gov/pubmed/33049227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.09.028
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