Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

Hotspot histone H3 mutations have emerged as drivers of oncogenesis in cancers of multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are recurrently identified in chondroblastomas, undifferentiated sarcomas, and head and neck cancers. While the mutation reduces global lev...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rajagopalan, Kartik N., Chen, Xiao, Weinberg, Daniel N., Chen, Haifen, Majewski, Jacek, Allis, C. David, Lu, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936350/
https://ncbi.nlm.nih.gov/pubmed/33619101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021795118
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