Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sarthy, Jay F, Meers, Michael P, Janssens, Derek H, Henikoff, Jorja G, Feldman, Heather, Paddison, Patrick J, Lockwood, Christina M, Vitanza, Nicholas A, Olson, James M, Ahmad, Kami, Henikoff, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518889/
https://ncbi.nlm.nih.gov/pubmed/32902381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61090
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