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GENE-06. THE ONCOHISTONE H3.3K27M DRIVES DIFFUSE INTRINSIC PONTINE GLIOMA INDEPENDENT OF FUNCTIONAL EZH2
BACKGROUND: Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable childhood brain tumor. Recent studies demonstrate that the replication independent oncohistone H3.3K27M, mutated in 65% of DIPG cases, inhibits Enhancer of zeste homolog 2 (EZH2), the enzymatic component of Polycomb Repressor Comple...
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| 發表在: | Neuro Oncol |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216477/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.433 |
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