Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver

Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethy...

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Publicat a:J Pharmacol Exp Ther
Autors principals: Xu, Meijuan, Bhatt, Deepak Kumar, Yeung, Catherine K., Claw, Katrina G., Chaudhry, Amarjit S., Gaedigk, Andrea, Pearce, Robin E., Broeckel, Ulrich, Gaedigk, Roger, Nickerson, Deborah A., Schuetz, Erin, Rettie, Allan E., Leeder, J. Steven, Thummel, Kenneth E., Prasad, Bhagwat
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
Matèries:
Metabolism, Transport, and Pharmacogenomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697103/
https://ncbi.nlm.nih.gov/pubmed/28819071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243113
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