Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex

The major objective of this study was to investigate the association of genetic and nongenetic factors with variability in protein abundance and in vitro activity of the androgen-metabolizing enzyme UGT2B17 in human liver microsomes (n = 455). UGT2B17 abundance was quantified by liquid chromatograph...

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Publicado en:Drug Metab Dispos
Main Authors: Bhatt, Deepak Kumar, Basit, Abdul, Zhang, Haeyoung, Gaedigk, Andrea, Lee, Seung-been, Claw, Katrina G., Mehrotra, Aanchal, Chaudhry, Amarjit Singh, Pearce, Robin E., Gaedigk, Roger, Broeckel, Ulrich, Thornton, Timothy A., Nickerson, Deborah A., Schuetz, Erin G., Amory, John K., Leeder, J. Steven, Prasad, Bhagwat
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938891/
https://ncbi.nlm.nih.gov/pubmed/29602798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.080952
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