Normalized testosterone glucuronide as a potential urinary biomarker for highly variable UGT2B17 in children 7 to 18 years

UDP-glucuronosyltransferase 2B17 (UGT2B17) is a highly variable androgen- and drug-metabolizing enzyme. UGT2B17 exhibits a unique ontogeny profile characterized by a dramatic increase in hepatic protein expression from pre-pubertal age to adulthood. Age, sex, copy number variation (CNV), and single...

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Vydáno v:Clin Pharmacol Ther
Hlavní autoři: Zhang, Haeyoung, Basit, Abdul, Wolford, Chris, Chen, Kuan-Fu, Gaedigk, Andrea, Lin, Yvonne S., Leeder, J Steven, Prasad, Bhagwat
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7167343/
https://ncbi.nlm.nih.gov/pubmed/31900930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1764
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