Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver

Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethy...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Xu, Meijuan, Bhatt, Deepak Kumar, Yeung, Catherine K., Claw, Katrina G., Chaudhry, Amarjit S., Gaedigk, Andrea, Pearce, Robin E., Broeckel, Ulrich, Gaedigk, Roger, Nickerson, Deborah A., Schuetz, Erin, Rettie, Allan E., Leeder, J. Steven, Thummel, Kenneth E., Prasad, Bhagwat
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697103/
https://ncbi.nlm.nih.gov/pubmed/28819071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243113
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