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Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

Hepatic cytosolic alcohol and aldehyde dehydrogenases (ADHs and ALDHs) catalyze the biotransformation of xenobiotics (e.g., cyclophosphamide and ethanol) and vitamin A. Because age-dependent hepatic abundance of these proteins is unknown, we quantified protein expression of ADHs and ALDH1A1 in a lar...

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Foilsithe in:Drug Metab Dispos
Main Authors: Bhatt, Deepak Kumar, Gaedigk, Andrea, Pearce, Robin E., Leeder, J. Steven, Prasad, Bhagwat
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2017
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563927/
https://ncbi.nlm.nih.gov/pubmed/28607029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.076463
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