Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

Hepatic cytosolic alcohol and aldehyde dehydrogenases (ADHs and ALDHs) catalyze the biotransformation of xenobiotics (e.g., cyclophosphamide and ethanol) and vitamin A. Because age-dependent hepatic abundance of these proteins is unknown, we quantified protein expression of ADHs and ALDH1A1 in a lar...

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Gepubliceerd in:Drug Metab Dispos
Hoofdauteurs: Bhatt, Deepak Kumar, Gaedigk, Andrea, Pearce, Robin E., Leeder, J. Steven, Prasad, Bhagwat
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563927/
https://ncbi.nlm.nih.gov/pubmed/28607029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.076463
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