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Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

Hepatic cytosolic alcohol and aldehyde dehydrogenases (ADHs and ALDHs) catalyze the biotransformation of xenobiotics (e.g., cyclophosphamide and ethanol) and vitamin A. Because age-dependent hepatic abundance of these proteins is unknown, we quantified protein expression of ADHs and ALDH1A1 in a lar...

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發表在:Drug Metab Dispos
Main Authors: Bhatt, Deepak Kumar, Gaedigk, Andrea, Pearce, Robin E., Leeder, J. Steven, Prasad, Bhagwat
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563927/
https://ncbi.nlm.nih.gov/pubmed/28607029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.076463
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