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Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa(1)-Arg-(pI)DPhe-Xaa(4)-NH(2)

The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa(1) -Arg-(pI)DPhe-Xaa(4) -NH(2)] is reported. The scaffold was...

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發表在:J Med Chem
Main Authors: Doering, Skye R., Freeman, Katie T., Schnell, Sathya M., Haslach, Erica M., Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Speth, Robert C, Houghten, Richard A., Haskell-Luevano, Carrie
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672800/
https://ncbi.nlm.nih.gov/pubmed/28453292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00301
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