Peptoid NPhe(4) in AGRP-Based c[Pro(1)-Arg(2)-Phe(3)-Phe(4)-Xxx(5)-Ala(6)-Phe(7)-DPro(8)] Scaffolds Maintain Mouse MC4R Antagonist Potency

av Ericson, Mark D., Freeman, Katie T., Haskell-Luevano, Carrie
I publikationen ACS Med Chem Lett (2020)

A Fragment of the Escherichia coli ClpB Heat-Shock Protein is a Micromolar Melanocortin 1 Receptor Agonist

av Ericson, Mark D., Schnell, Sathya M., Freeman, Katie T., Haskell-Luevano, Carrie
I publikationen Bioorg Med Chem Lett (2015)

A Macrocyclic Agouti-Related Protein/[Nle4, DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Sub-nanomolar Melanocortin Receptor Ligands

av Ericson, Mark D., Freeman, Katie T., Schnell, Sathya M., Haskell-Luevano, Carrie
I publikationen J Med Chem (2017)

Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Sele...

av Fleming, Katlyn A., Freeman, Katie T., Ericson, Mark D., Haskell-Luevano, Carrie
I publikationen J Med Chem (2018)

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy

av Winget, Marshall D., Ericson, Mark D., Freeman, Katie T., Haskell-Luevano, Carrie
I publikationen ACS Med Chem Lett (2019)

Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH(2) Sequence

av Singh, Anamika, Tala, Srinivasa R., Flores, Viktor, Freeman, Katie, Haskell-Luevano, Carrie
I publikationen ACS Med Chem Lett (2015)

Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation

av Zhang, Hua, Fagan, Dedra H., Zeng, Xianke, Freeman, Katie T., Sachdev, Deepali, Yee, Douglas
Publicerad 2010

Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

av Ericson, Mark D., Shaikh, Romessa, Larson, Courtney M., Freeman, Katie T., Haskell-Luevano, Carrie
I publikationen ACS Med Chem Lett (2020)

Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4...

av Ericson, Mark D., Freeman, Katie T., Schnell, Sathya M., Fleming, Katlyn A., Haskell-Luevano, Carrie
I publikationen J Med Chem (2017)

Arg-Phe-Phe D-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-DPro] Results in Unanticipated Melanocorti...

av Ericson, Mark D., Koerperich, Zoe M., Freeman, Katie T., Fleming, Katlyn A., Haskell-Luevano, Carrie
I publikationen ACS Chem Neurosci (2018)

Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs

av Alkanfari, Ibrahim, Freeman, Katie B., Roy, Saptarshi, Jahan, Tahsin, Scott, Richard W., Ali, Hydar
I publikationen Cells (2019)

Baseline Predictors of Clinical Progression among Patients with Dysexecutive Mild Cognitive Impairment

av Johnson, Julene K., Pa, Judy, Boxer, Adam L., Kramer, Joel H., Freeman, Katie, Yaffe, Kristine
Publicerad 2010

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin2 Recruitment) Within the Melanocortin...

av Lensing, Cody J., Freeman, Katie T., Schnell, Sathya M., Speth, Robert C., Zarth, Adam T., Haskell-Luevano, Carrie
I publikationen J Med Chem (2018)

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH(2) at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus...

av Schlasner, Katherine N., Ericson, Mark D., Doering, Skye R., Freeman, Katie T., Weinrich, Mary, Haskell-Luevano, Carrie
I publikationen Molecules (2019)

An in vitro and in vivo investigation of bivalent ligands that display preferential binding and functional activity for different melanocortin receptor homodimers

av Lensing, Cody J., Freeman, Katie T., Schnell, Sathya M., Adank, Danielle N., Speth, Robert C., Haskell-Luevano, Carrie
I publikationen J Med Chem (2016)

1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization

av Tala, Srinivasa R., Singh, Anamika, Lensing, Cody J., Schnell, Sathya M., Freeman, Katie T., Rocca, James R., Haskell-Luevano, Carrie
I publikationen ACS Chem Neurosci (2018)

Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor

av Khalil, Shadi, Delehanty, Lorrie, Grado, Stephen, Holy, Maja, White, Zollie, Freeman, Katie, Kurita, Ryo, Nakamura, Yukio, Bullock, Grant, Goldfarb, Adam
I publikationen J Exp Med (2018)

Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists an...

av Fleming, Katlyn A., Ericson, Mark D., Freeman, Katie T., Adank, Danielle N., Lunzer, Mary M., Wilber, Stacey L., Haskell-Luevano, Carrie
I publikationen ACS Chem Neurosci (2018)

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases M...

av Koerperich, Zoe M., Ericson, Mark D., Freeman, Katie T., Speth, Robert C., Pogozheva, Irina D., Mosberg, Henry I., Haskell-Luevano, Carrie
I publikationen J Med Chem (2020)

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

av Ghilardi, Joseph R, Freeman, Katie T, Jimenez-Andrade, Juan M, Mantyh, William G, Bloom, Aaron P, Kuskowski, Michael A, Mantyh, Patrick W
Publicerad 2010