Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

Lignende værker

• Melanocortin Antagonist Tetrapeptides with Minimal Agonist Activity at the Mouse Melanocortin-3 Receptor
  af: Doering, Skye R., et al.
  Udgivet: (2014)
• Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy
  af: Winget, Marshall D., et al.
  Udgivet: (2019)
• A Fragment of the Escherichia coli ClpB Heat-Shock Protein is a Micromolar Melanocortin 1 Receptor Agonist
  af: Ericson, Mark D., et al.
  Udgivet: (2015)
• Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists
  af: Fleming, Katlyn A., et al.
  Udgivet: (2018)
• Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor
  af: Ericson, Mark D., et al.
  Udgivet: (2017)