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Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

[Image: see text] The five melanocortin receptors regulate numerous physiological functions. Although many ligands have been developed for the melanocortin-4 receptor (MC4R), the melanocortin-3 receptor (MC3R) has been less-well characterized, in part due to the lack of potent, selective tool compou...

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Publicat a:ACS Med Chem Lett
Autors principals: Ericson, Mark D., Shaikh, Romessa, Larson, Courtney M., Freeman, Katie T., Haskell-Luevano, Carrie
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812669/
https://ncbi.nlm.nih.gov/pubmed/33488972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00561
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