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Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation
Insulin receptor (IR) and the type I IGF receptor (IGF1R) are structurally and functionally related. The function of IGF1R in cancer has been well documented and anti-IGF1R strategies to treat cancer have shown initial positive results. However, the role of IR in tumor biology, independent of IGF1R,...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2861724/ https://ncbi.nlm.nih.gov/pubmed/20154728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.17 |
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