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Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation

Insulin receptor (IR) and the type I IGF receptor (IGF1R) are structurally and functionally related. The function of IGF1R in cancer has been well documented and anti-IGF1R strategies to treat cancer have shown initial positive results. However, the role of IR in tumor biology, independent of IGF1R,...

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Autors principals: Zhang, Hua, Fagan, Dedra H., Zeng, Xianke, Freeman, Katie T., Sachdev, Deepali, Yee, Douglas
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861724/
https://ncbi.nlm.nih.gov/pubmed/20154728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.17
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