Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists that Increase Food Intake in Mice

The melanocortin system has five receptors and antagonists of the central melanocortin receptors (MC3R, MC4R) are postulated to be viable therapeutics for disorders of negative energy balance such as anorexia, cachexia, and failure to thrive. Agouti-related protein (AGRP) is an antagonist of the MC3...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Fleming, Katlyn A., Ericson, Mark D., Freeman, Katie T., Adank, Danielle N., Lunzer, Mary M., Wilber, Stacey L., Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955836/
https://ncbi.nlm.nih.gov/pubmed/29363944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00495
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