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Arg-Phe-Phe D-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles

The melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R), endogenous agonists derived from the proopiomelanocortin gene transcript, and naturally-occurring antagonists agouti and agouti-related protein (AGRP) have been linked to biological pathways associated with energy homeostasis. The acti...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Ericson, Mark D., Koerperich, Zoe M., Freeman, Katie T., Fleming, Katlyn A., Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339850/
https://ncbi.nlm.nih.gov/pubmed/29924583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00218
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