Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa(1)-Arg-(pI)DPhe-Xaa(4)-NH(2)

The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa(1) -Arg-(pI)DPhe-Xaa(4) -NH(2)] is reported. The scaffold was...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Doering, Skye R., Freeman, Katie T., Schnell, Sathya M., Haslach, Erica M., Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Speth, Robert C, Houghten, Richard A., Haskell-Luevano, Carrie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672800/
https://ncbi.nlm.nih.gov/pubmed/28453292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00301
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