Discovery of Polypharmacological Melanocortin-3 and −4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a µM MC4R Partial Agonist

The centrally expressed melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are established targets to treat diseases of positive and negative energy homeostasis. We previously reported (J. Med. Chem. 60:4342 2017) mixture-based positional scanning approaches to identify dual MC3R agonist and M...

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Publicado no:J Med Chem
Main Authors: Fleming, Katlyn A., Freeman, Katie T., Powers, Mike D., Santos, Radleigh G., Debevec, Ginamarie, Giulianotti, Marc A., Houghten, Richard A., Doering, Skye R., Pinilla, Clemencia, Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463894/
https://ncbi.nlm.nih.gov/pubmed/30741545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00053
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