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Structure-Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5,800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R)

The melanocortin-3 (MC3) and melanocortin-4 (MC4) receptors regulate energy homeostasis, food intake, and associated physiological conditions. The MC4R has been studied extensively. Less is known about specific physiological roles of the MC3R. A major obstacle to this lack of knowledge is attributed...

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Detaylı Bibliyografya
Asıl Yazarlar: Singh, Anamika, Dirain, Marvin, Witek, Rachel, Rocca, James R., Edison, Arthur S, Haskell-Luevano, Carrie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652311/
https://ncbi.nlm.nih.gov/pubmed/23432160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301253y
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