Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)

[Image: see text] Human obesity has been linked to genetic factors and single nucleotide polymorphisms (SNPs). Melanocortin-4 receptor (MC4R) SNPs have been associated with up to 6% frequency in morbidly obese children and adults. A potential therapy for individuals possessing such genetic modificat...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Haslach, Erica M., Huang, Huisuo, Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Doering, Skye R., Walters, Michael A., Houghten, Richard A., Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324447/
https://ncbi.nlm.nih.gov/pubmed/24517312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500064t
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