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Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa(1)-Arg-(pI)DPhe-Xaa(4)-NH(2)

The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa(1) -Arg-(pI)DPhe-Xaa(4) -NH(2)] is reported. The scaffold was...

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Publicado no:J Med Chem
Main Authors: Doering, Skye R., Freeman, Katie T., Schnell, Sathya M., Haslach, Erica M., Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Appel, Jon R., Speth, Robert C, Houghten, Richard A., Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672800/
https://ncbi.nlm.nih.gov/pubmed/28453292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00301
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