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p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant myopathy caused by mutations that disrupt repression of the normally silent DUX4 gene, which encodes a transcription factor that has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts and t...
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| Publicado en: | Dis Model Mech |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Company of Biologists Ltd
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5665455/ https://ncbi.nlm.nih.gov/pubmed/28754837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.030064 |
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