p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant myopathy caused by mutations that disrupt repression of the normally silent DUX4 gene, which encodes a transcription factor that has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts and t...

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Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Bosnakovski, Darko, Gearhart, Micah D., Toso, Erik A., Recht, Olivia O., Cucak, Anja, Jain, Abhinav K., Barton, Michelle C., Kyba, Michael
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665455/
https://ncbi.nlm.nih.gov/pubmed/28754837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.030064
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