A defective mRNA cleavage and polyadenylation complex facilitates expansions of transcribed (GAA)(n) repeats associated with Friedreich’s ataxia

Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich’s ataxia. While the length of an expandable repeat is the main factor determining disease inheritance, recent data point to genomic trans-modifiers that can im...

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Опубликовано в: :Cell Rep
Главные авторы: McGinty, Ryan J., Puleo, Franco, Aksenova, Anna Y., Hisey, Julia A., Shishkin, Alexander A., Pearson, Erika L., Wang, Eric T., Housman, David E., Moore, Claire, Mirkin, Sergei M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658003/
https://ncbi.nlm.nih.gov/pubmed/28877480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.051
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