A defective mRNA cleavage and polyadenylation complex facilitates expansions of transcribed (GAA)(n) repeats associated with Friedreich’s ataxia

Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich’s ataxia. While the length of an expandable repeat is the main factor determining disease inheritance, recent data point to genomic trans-modifiers that can im...

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Publicat a:Cell Rep
Autors principals: McGinty, Ryan J., Puleo, Franco, Aksenova, Anna Y., Hisey, Julia A., Shishkin, Alexander A., Pearson, Erika L., Wang, Eric T., Housman, David E., Moore, Claire, Mirkin, Sergei M.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658003/
https://ncbi.nlm.nih.gov/pubmed/28877480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.051
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