Large-scale expansions of Friedreich’s ataxia GAA repeats in yeast

Large-scale expansions of DNA repeats are implicated in numerous hereditary disorders in humans. We describe a yeast experimental system to analyze large-scale expansions of triplet GAA repeats, responsible for the human disease Friedreich’s ataxia. When GAA repeats were placed into an intron of the...

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Detalhes bibliográficos
Main Authors: Shishkin, Alexander A., Voineagu, Irina, Matera, Robert, Cherng, Nicole, Chernet, Brook T., Krasilnikova, Maria M., Narayanan, Vidhya, Lobachev, Kirill S., Mirkin, Sergei M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722067/
https://ncbi.nlm.nih.gov/pubmed/19595718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.017
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