Effects of Friedreich's ataxia (GAA)(n)·(TTC)(n) repeats on RNA synthesis and stability

Expansions of (GAA)(n) repeats within the first intron of the frataxin gene reduce its expression, resulting in a hereditary neurodegenerative disorder, Friedreich's ataxia. While it is generally believed that expanded (GAA)(n) repeats block transcription elongation, fine mechanisms responsible...

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Autori principali: Krasilnikova, Maria M., Kireeva, Maria L., Petrovic, Vladimir, Knijnikova, Nelli, Kashlev, Mikhail, Mirkin, Sergei M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2007
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851639/
https://ncbi.nlm.nih.gov/pubmed/17264130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1140
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