Friedreich's Ataxia (GAA)(n)•(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae

Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeast about 10,000-fold relative to a “normal” DNA sequ...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tang, Wei, Dominska, Margaret, Greenwell, Patricia W., Harvanek, Zachary, Lobachev, Kirill S., Kim, Hyun-Min, Narayanan, Vidhya, Mirkin, Sergei M., Petes, Thomas D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020933/
https://ncbi.nlm.nih.gov/pubmed/21249181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001270
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