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Friedreich's Ataxia (GAA)(n)•(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae
Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeast about 10,000-fold relative to a “normal” DNA sequ...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3020933/ https://ncbi.nlm.nih.gov/pubmed/21249181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001270 |
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