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Friedreich's Ataxia (GAA)(n)•(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae

Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeast about 10,000-fold relative to a “normal” DNA sequ...

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書誌詳細
主要な著者: Tang, Wei, Dominska, Margaret, Greenwell, Patricia W., Harvanek, Zachary, Lobachev, Kirill S., Kim, Hyun-Min, Narayanan, Vidhya, Mirkin, Sergei M., Petes, Thomas D.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020933/
https://ncbi.nlm.nih.gov/pubmed/21249181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001270
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