Friedreich's Ataxia (GAA)(n)•(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae

Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeast about 10,000-fold relative to a “normal” DNA sequ...

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Autori principali: Tang, Wei, Dominska, Margaret, Greenwell, Patricia W., Harvanek, Zachary, Lobachev, Kirill S., Kim, Hyun-Min, Narayanan, Vidhya, Mirkin, Sergei M., Petes, Thomas D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020933/
https://ncbi.nlm.nih.gov/pubmed/21249181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001270
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