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RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)(n) repeats via break-induced replication
Expansion of simple DNA repeats is responsible for numerous hereditary diseases in humans. The role of DNA replication, repair and transcription in the expansion process has been well documented. Here we analyzed, in a yeast experimental system, the role of RNA–DNA hybrids in genetic instability of...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909440/ https://ncbi.nlm.nih.gov/pubmed/29447396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky099 |
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