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DNA ligase IV guides end-processing choice during nonhomologous end joining
Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here we investigate the mechanistic basis for this flexibility. DNA ends are aligned in a paired-end complex (PEC) by Ku, XLF, XRCC4, and DNA ligase IV (LIG4); we show by single-molecule analysi...
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| 出版年: | Cell Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5649367/ https://ncbi.nlm.nih.gov/pubmed/28930678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.091 |
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