DNA ligase IV guides end-processing choice during nonhomologous end joining

Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here we investigate the mechanistic basis for this flexibility. DNA ends are aligned in a paired-end complex (PEC) by Ku, XLF, XRCC4, and DNA ligase IV (LIG4); we show by single-molecule analysi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Conlin, Michael P., Reid, Dylan A., Small, George W., Chang, Howard H., Watanabe, Go, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649367/
https://ncbi.nlm.nih.gov/pubmed/28930678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.091
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