DNA ligase IV guides end-processing choice during nonhomologous end joining

Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here we investigate the mechanistic basis for this flexibility. DNA ends are aligned in a paired-end complex (PEC) by Ku, XLF, XRCC4, and DNA ligase IV (LIG4); we show by single-molecule analysi...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Conlin, Michael P., Reid, Dylan A., Small, George W., Chang, Howard H., Watanabe, Go, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649367/
https://ncbi.nlm.nih.gov/pubmed/28930678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.091
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