Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

The Nonhomologous end joining (NHEJ) pathway preserves genome stability by ligating the ends of broken chromosomes together. It employs end-processing enzymes, including polymerases, to prepare ends for ligation. We show two such polymerases primarily incorporate ribonucleotides during NHEJ - an exc...

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Vydáno v:Science
Hlavní autoři: Pryor, John M., Conlin, Michael P., Carvajal-Garcia, Juan, Luedeman, Megan E., Luthman, Adam J., Small, George W., Ramsden, Dale A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252249/
https://ncbi.nlm.nih.gov/pubmed/30213916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat2477
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