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Essential role for polymerase specialization in cellular nonhomologous end joining

Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face of extensive diversity in broken end structures. We show here that this flexibility is often reliant on the ability to direct DNA synthesis across strand breaks, and that polymerase (Pol) μ and Pol λ are...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pryor, John M., Waters, Crystal A., Aza, Ana, Asagoshi, Kenjiro, Strom, Christina, Mieczkowski, Piotr A., Blanco, Luis, Ramsden, Dale A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547266/
https://ncbi.nlm.nih.gov/pubmed/26240371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505805112
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