Essential role for polymerase specialization in cellular nonhomologous end joining

Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face of extensive diversity in broken end structures. We show here that this flexibility is often reliant on the ability to direct DNA synthesis across strand breaks, and that polymerase (Pol) μ and Pol λ are...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pryor, John M., Waters, Crystal A., Aza, Ana, Asagoshi, Kenjiro, Strom, Christina, Mieczkowski, Piotr A., Blanco, Luis, Ramsden, Dale A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
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PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547266/
https://ncbi.nlm.nih.gov/pubmed/26240371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505805112
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