Essential role for polymerase specialization in cellular nonhomologous end joining

Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face of extensive diversity in broken end structures. We show here that this flexibility is often reliant on the ability to direct DNA synthesis across strand breaks, and that polymerase (Pol) μ and Pol λ are...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Pryor, John M., Waters, Crystal A., Aza, Ana, Asagoshi, Kenjiro, Strom, Christina, Mieczkowski, Piotr A., Blanco, Luis, Ramsden, Dale A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547266/
https://ncbi.nlm.nih.gov/pubmed/26240371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505805112
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