Essential role for polymerase specialization in cellular nonhomologous end joining

Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face of extensive diversity in broken end structures. We show here that this flexibility is often reliant on the ability to direct DNA synthesis across strand breaks, and that polymerase (Pol) μ and Pol λ are...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Pryor, John M., Waters, Crystal A., Aza, Ana, Asagoshi, Kenjiro, Strom, Christina, Mieczkowski, Piotr A., Blanco, Luis, Ramsden, Dale A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547266/
https://ncbi.nlm.nih.gov/pubmed/26240371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505805112
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