Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA double-strand breaks (DSBs), involving synapsis and ligation of the broken strands. We describe the use of in vivo and in vitro single-molecule methods to define the organization and interaction of NHEJ repair proteins at DSB ends. S...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Reid, Dylan A., Keegan, Sarah, Leo-Macias, Alejandra, Watanabe, Go, Strande, Natasha T., Chang, Howard H., Oksuz, Betul Akgol, Fenyo, David, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443322/
https://ncbi.nlm.nih.gov/pubmed/25941401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420115112
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