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Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining
The Nonhomologous end joining (NHEJ) pathway preserves genome stability by ligating the ends of broken chromosomes together. It employs end-processing enzymes, including polymerases, to prepare ends for ligation. We show two such polymerases primarily incorporate ribonucleotides during NHEJ - an exc...
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| Опубликовано в: : | Science |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6252249/ https://ncbi.nlm.nih.gov/pubmed/30213916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat2477 |
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