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The molecular basis and disease relevance of non-homologous DNA end joining
Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type of DNA double-strand break (DSB) during most of the cell cycle and is essential for the development of antigen receptors. Defects in NHEJ result in sensitivity to ionizing radiation and loss of lymphocytes. The mos...
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| Published in: | Nat Rev Mol Cell Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8063501/ https://ncbi.nlm.nih.gov/pubmed/33077885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-020-00297-8 |
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