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The molecular basis and disease relevance of non-homologous DNA end joining

Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type of DNA double-strand break (DSB) during most of the cell cycle and is essential for the development of antigen receptors. Defects in NHEJ result in sensitivity to ionizing radiation and loss of lymphocytes. The mos...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Mol Cell Biol
Prif Awduron: Zhao, Bailin, Rothenberg, Eli, Ramsden, Dale A., Lieber, Michael R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063501/
https://ncbi.nlm.nih.gov/pubmed/33077885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-020-00297-8
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