DNA ligase IV guides end-processing choice during nonhomologous end joining

Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here we investigate the mechanistic basis for this flexibility. DNA ends are aligned in a paired-end complex (PEC) by Ku, XLF, XRCC4, and DNA ligase IV (LIG4); we show by single-molecule analysi...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Conlin, Michael P., Reid, Dylan A., Small, George W., Chang, Howard H., Watanabe, Go, Lieber, Michael R., Ramsden, Dale A., Rothenberg, Eli
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649367/
https://ncbi.nlm.nih.gov/pubmed/28930678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.091
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